Propandrol (Testosterone P) 1 bottle/10 ml (100 mg/1 ml)


Propandrol (old name: Testosterone P) (testosterone propionate) from Balkan Pharma is an ester of the male sex hormone testosterone, produced in a convenient 10 ml bottle, the half-life of which is about 48 hours. Thus, this is the fastest ego oil ether, faster than only the testosterone suspension (it is in this form that testosterone is found in our body). Testosterone P begins to act almost immediately, the high concentration of the drug is maintained for 24-48 hours.

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Testosterone propionate begins its action immediately after injection and lasts for 24 hours. In the blood, almost 98% of testosterone binds to a specific fraction of globulins that binds testosterone and estradiol. Biotransformation occurs in the liver to various 17-ketosteroids, which after conjugation with glucuronic or sulfuric acid are excreted in the urine (approximately 90%). About 6% of the absorbed drug is excreted with feces in an unbound form.


In men androgen insufficiency after castration, eunuchoidism, impotence of hormonal origin, symptoms of male menopause (decrease in libido, mental and physical activity), in acromegaly, in hypertrophy of the prostate gland, osteoporosis caused by androgen insufficiency, in angioneurotic forms of angina pectoris.

In women in climacteric vascular and nervous disorders in cases where estrogenic drugs are contraindicated (in tumors of the genital organs and mammary glands, uterine bleeding), simultaneously with radiation therapy in breast and ovarian cancer (usually in women under the age of 60), in dysfunctional uterine bleeding in elderly women.

Pharmacokinetic properties of Testosterone Propionate

Intramuscularly, deep into the gluteal muscle. The dose is set individually depending on the indications and the patient's reaction.

Men with eunuchoidism, congenital underdevelopment of the gonads, their removal by surgery or as a result of trauma, as well as with acromegaly are prescribed 25 mg daily or 50 mg every other day or every 2 days. The duration of treatment depends on the effectiveness of therapy and the nature of the disease. Treatment is usually carried out over a long period of time. After improvement of the clinical picture, testosterone propionate is administered in maintenance doses: 5-10 mg daily or every other day.

For impotence due to functional insufficiency of the gonads, fatigue and nervous exhaustion, as well as for male climacteric syndrome, 10 mg daily or 25 mg 2-3 times a week for 1-2 months are prescribed.

With hypertrophy of the prostate gland in the initial stage, take 10 mg every other day for 1-2 months.

In patients with angina pectoris, a positive effect is sometimes observed when using testosterone 10 – 12.5 mg once a week, with good tolerance, the number of injections is increased to two per week (within 3 – 5 weeks). By the end of the treatment, the dose and number of injections are reduced again. The course of treatment consists of 15-20 injections.

Women older than 45 years with dysfunctional uterine bleeding are prescribed 10-25 mg every other day for 20-30 days until the bleeding stops and atrophic cells appear in vaginal smears. Malignant neoplasms of the uterus should be ruled out beforehand.

With vascular and nervous disorders of climacteric origin in women and contraindications to the use of estrogens, testosterone propionate is administered 10 mg every other day or 25 mg 2 times a week for 2-3 weeks.

With malignant tumors of the mammary gland or ovaries, testosterone propionate is administered in a dose of 50 mg daily for several months, then (depending on the results of the treatment) the dose is reduced and maintenance doses are prescribed for a long time. As an adjunct to surgery or radiation therapy, the drug is prescribed to women under 60 years of age (older women are recommended to take estrogens).

Higher doses intramuscularly for adults: single 50 mg, daily 100 mg.

The drug cannot be administered intravenously!

Side effects

  • Priapism and other signs of excessive sexual stimulation (frequent erection),
  • in prepubescent boys, accelerated sexual development, increased frequency of erections, penis enlargement and premature closure of the epiphyses,
  • damage to spermatogenesis and impaired maturation of spermatozoa, oligospermia and a decrease in ejaculate volume,
  • abnormalities of the prostate gland,
  • in women, bleeding from the birth canal, increased libido, with prolonged use of the drug, symptoms of virilization are possible,
  • hirsutism, gynecomastia,
  • seborrhea, acne, oily skin, accelerated hair loss,
  • sodium and water retention, edema,
  • symptoms of hypercalcemia,
  • thrombophlebitis,
  • nausea, cholestatic jaundice, an increase in the level of liver aminotransferases (they normalize as the intake is stopped),
  • headache, depression, aggressiveness, anxiety, sleep disturbance, paresthesia.
  • Pain, itching and hyperemia at the injection site are possible.


increased individual sensitivity to the components of the drug, carcinoma of the prostate or breast gland, nephrosis or the nephrotic phase of nephritis, edema, hypercalcemia, impaired liver function, diabetes mellitus, heart and coronary insufficiency, a history of myocardial infarction, atherosclerosis in elderly men, pregnancy, breastfeeding.


With an acute overdose, the toxicity of testosterone is extremely low.

With a chronic overdose, the development of priapism is possible. In this case, the treatment should be stopped, and after the disappearance of symptoms – start in smaller doses.

Precautions and special applications

In case of androgen-dependent side reactions, treatment with testosterone should be stopped. After the disappearance of side effects, the treatment will be resumed in lower doses.

Patients with latent or severe heart failure, impaired kidney function, hypertension, epilepsy or migraine (or the presence of these conditions in the anamnesis) are subject to constant observation, as androgens can in some cases cause sodium and water retention. With long-term use, liver function will be checked. In patients with breast cancer, hypernephroma, lung cancer with metastases in the bones, the level of calcium in the blood and urine will be checked.

In prepubescent boys, androgens should be used with caution to avoid premature closure of the epiphyses and accelerated sexual development.

Interaction with other drugs

Increases the effectiveness of anticoagulants and hypoglycemic agents (it is necessary to change the doses), inhibits the excretion of cyclosporine. Liver enzyme inducers (barbiturates, rifampicin, carbamazepine, phenylbutazone, phenytoin) reduce the effect of testosterone.

Storage conditions

Store at a temperature of 15-25C, in a dry place protected from light and inaccessible to children.

Expiry date

5 years Do not use after the expiration date indicated on the package.


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