Description
Tablets of yellow color, square shape, flat on both sides and chamfered, engraved with BP on one side, and 50 on the other, with rounded edges. Marbling on the surface of the tablets is allowed.
Medicinal form Tablets.
Pharmacotherapeutic group and ath code
Steroid anabolic, A14A A05.
Pharmacological properties
Oxymetholone is a steroid anabolic. Penetrating inside the cell nucleus, it activates the genetic apparatus of the cell, which leads to an increase in the synthesis of DNA, RNA and structural proteins, activation of enzymes of the tissue respiration chain and enhancement of tissue respiration, oxidative phosphorylation, ATP synthesis and accumulation of macroergs inside the cell. Stimulates anabolic and suppresses catabolic processes caused by glucocorticoids. It leads to an increase in muscle mass, a decrease in fat deposits, improves tissue trophism, promotes calcium deposition in bones, and retains sodium and water in the body. Hematopoietic action is associated with an increase in the synthesis of erythropoietin. Androgenic activity (low) can contribute to the development of secondary sexual characteristics of the male type.
Indications
Violations of protein synthesis, cachexia of various origins, injuries, extensive burns, after infectious diseases and radiation, muscular dystrophy, osteoporosis, negative nitrogen balance during corticosteroid therapy, hypo- and aplastic anemia.
Method of application and dosage
Adults are prescribed in a dose of 2-3 mg/kg. The duration of treatment is 3 months and can be extended depending on the result.
Side effects
In women, symptoms of virilization, suppression of ovarian function, menstrual cycle disorders, hypercalcemia.
In men: in the prepubertal period, symptoms of virilization, idiopathic skin hyperpigmentation, growth retardation or cessation (calcification of the epiphyseal growth zones of tubular bones), in the postpubertal period, bladder irritation, gynecomastia, priapism, in old age, hypertrophy and/or carcinoma of the prostate gland.
In men and women, the progression of atherosclerosis, peripheral edema, dyspeptic disorders, impaired liver function with jaundice, changes in the leukocyte formula, pain in long tubular bones, hypocoagulation with a tendency to bleeding.
Contraindications
Increased sensitivity to the drug, prostate cancer, breast cancer in men, carcinoma of the breast in women with hypercalcemia, coronary artery disease, severe atherosclerosis, nephritis, nephrotic syndrome, liver and kidney failure, acute and chronic prostatitis, pregnancy, breastfeeding.
Overdose
Cases of overdose are not registered.
Precautions and special applications
When the first signs of virilization appear in women (roughening of the voice, hirsutism, acne, clitoromegaly), the reception should be stopped to prevent irreversible changes. Suppression of blood coagulation factors II, VII, VII and X and an increase in prothrombin time may occur. Periodically check the level of lipidemia and cholesterolemia. For children, the drug should be prescribed by an experienced specialist to prevent premature ossification of the epiphyses of the bones.
Interaction with other drugs
Glucocorticoids, mineralocorticoids, corticotropin, sodium-containing drugs and food rich in sodium potentiate fluid retention in the body, increase the risk of edema development, and increase the severity of acne breakouts. Strengthens the effects of antiplatelets, indirect anticoagulants, insulin, and oral antidiabetic agents, weakens somatotropin and its derivatives.
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